Leveraging Nanoparticle Technologies for Novel Vaccines & Therapies ePanel

Nanoparticles are emerging as a powerful mode of delivery for drugs, vaccines and even gene therapy, enabling the delivery of a wide variety of therapeutic agents beyond small molecules. On April 27th Keystone Symposia hosted a free ePanel to explore recent breakthroughs in nanoparticle technology, design and applications, opening the door to new therapeutic modalities deploying nucleic acids to treat disease. The discussion integrated academic and industry perspectives, examining the trajectory from bench to bedside, focusing the COVID-19 mRNA vaccine as a recent success story.

The ePanel featured pioneering work by Dr. Philip Felgner, Dr. Terry Allen and Dr. Pieter Cullis.  Dr. Cullis is this year's winner of the VinFuture Grand Prize, which honors exceptional minds whose breakthrough scientific research, and technological innovations have enormous potential to create meaningful change at scale.

The vision for the VinFuture Prize is to catalyze meaningful change in people’s everyday lives through tangible and highly scalable improvements in areas such as productivity, prosperity, connectivity, health, safety, environment, sustainability, as well as their overall happiness regardless of socioeconomic status.

Find out more about the panelists below and watch their SciTalk presentation from the event!

Watch the full ePanel event recording: 

Additional Background Reading on Lipid Nanoparticle Therapies:

https://www.exeleadbiopharma.com/news/liposomes-and-lipid-nanoparticles-as-delivery-vehicles-for-personalized-medicine

Meet the Panelists

Pieter Cullis, PhD, FRSC, FNAI

Read more about Dr. Cullis' accomplishments and the VinFuture Prize HERE

Philip Felgner, PhD

• Director of Protein Microarray Laboratory, Infectious Diseases, School of Medicine
• Project Scientist, Epidemiology, School of Medicine
• Director of Vaccine Research and Development Center, University of California, Irvine
• Chair of NIH Study Section: 'Gene and Drug Delivery Systems’

Dr. Felgner made a series of remarkable discoveries that launched active fields of scientific research that didn’t exist before his seminal work. His work is rooted in biophysics of the structure and hydrodynamic properties of bilayer membranes. In 1984 there were no positively charged bilayer forming lipids available in nature to prepare positively charged lipid vesicles. He collaborated with chemists at Syntex Research Institute to synthesize and characterize a series of positively charged bilayer forming lipids. When these vesicles interact with negatively charged nucleic acid the lipids and the nucleic acid reorganize together into a new structure, he called Lipoplex capturing 100% of the input nucleic acid. 

Lipoplexes are synthetic virus-like particles that deliver functional nucleic acid into cultured cells and ‘Lipofection’ has since become the most widely used in vitro transfection method. Felgner published highly cited reports showing functional gene transfer of plasmid DNA and mRNA into mouse muscle in vivo. This work spawned a separate field of nucleic acid vaccine science which culminated in the COVID LNP mRNA vaccines. 

More recently Felgner developed a protein microarray platform to measure vaccine induced antigen specific antibody levels against thousands of individual antigens. At the beginning of the COVID outbreak his Coronavirus Antigen Microarray was poised to measure SARS-CoV-2 mRNA vaccine induced Ab levels against dozens of respiratory virus antigens. His work chronicles a remarkable period of non-viral nucleic acid delivery and vaccine science, breaking the mRNA tabu, and culminating in the phenomenal success of mRNA vaccines important to the world today.

Theresa Allen, PhD, FRSC

• Chair of the Research Management Committee of the Nanomedicine Innovation Network (NMIN)
• Co-Founder and Strategic Advisor, Centre for Drug Research and Development (CDRD), Vancouver
• Visiting Professor, NanoMedicines Research Group, Dept. of Biochemistry & Molecular Biology, UBC, Vancouver
• Professor Emeritus, Pharmacology & Oncology, University of Alberta, Edmonton
  
  

  Theresa Mary (Terry) Allen is a Professor Emerita of Pharmacology and Oncology at the University of Alberta, a visiting professor at UBC, and the chair of the Research Management Committee of the Nanomedicine Innovation Network (NMIN). She has been active in the drug-delivery field for over 45 years, and has made important contributions to the development of long-circulating liposomes and ligand-targeted nanomedicines for anticancer drugs and gene medicines. She has over 200 peer-reviewed publications and is an inventor on several patents. The product DoxilÒ, the first anticancer nanomedicine approved in the world, came out of pioneering research in her laboratory at the University of Alberta. Her research on the development of long-circulating ligand-targeted therapeutics for small molecule therapeutics and gene medicines is widely recognized. She is a founding member of the CDRD (www.cdrd.ca), a novel hybrid organization devoted to advancing promising medical discoveries from academia to a commercially attractive stage. She has been an invited speaker at numerous national and international conferences, at universities and biotechnology companies and major pharmaceutical companies and has assisted in the organization of many international conferences in the nanomedicine field. Dr. Allen is a Fellow of the Royal Society of Canada and of the Controlled Release Society, and has won a number of national and international awards.

Read more about Dr. Allen's work here:

https://www.controlledreleasesociety.org/news/still-room-bottom-nano-particles-macro-impacts

Watch the free ePanel event On Demand Below!

This ePanel event is organized in collaboration with: